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. 2020 Jun 28;13(6):969–980. doi: 10.1093/ckj/sfaa049

FIGURE 1.

FIGURE 1

EGFR, VEGF, TKI and mTOR signaling pathways: Akt, protein kinase B (PKB); C-Kit, mast/stem cell growth factor receptor; DAG, diacyl glycerol; ERB, EGFR related-receptor protein (Her2Neu is on type of this); MAPK, mitogen-activated protein kinase; Mek, dual threonine and tyrosine recognition kinase; NOS, nitric oxide synthase; PKC, protein kinase C; PDGFR, platelet-derived growth factor receptor; PI3, phosphatidylinositol-4,5-bisphosphate 3-kinase; PLCϒ, phospholipase C-gamma; RAF, serine/threonine kinase/cellular homolog of viral RAF gene; RAS, rat sarcoma protein; VEGF A–D, vascular endothelial growth factor A–D; VEGFR 1–3, vascular endothelial growth factor receptor 1–3. Adapted from Selamet et al. [10].