Table 3.
Epidemiological, clinical, biochemical parameters and cause of death according to the three proposed genotypes
| Variable | High-risk phenotype (n = 75) | All others (n = 846) | Low-risk phenotype (n = 95) | P-value |
|---|---|---|---|---|
| rs562020 GG/AG + rs2320762 GG + rs2283368 CC/CT | rs562020 AA + rs2320762 GT/TT + rs2283368 TT | |||
| Age (years) | 57.43 (12.32) | 56.98 (13.28) | 57.45 (11.91) | 0.957 |
| Sex (female), n (%) | 30 (40) | 325 (38.4) | 41 (43.2) | 0.656 |
| Smoking (yes), n (%) | 47 (62.7) | 484 (57.2) | 46 (48.4) | 0.147 |
| Diabetes (yes), n (%) | 17 (22.7) | 191 (22.6) | 22 (23.2) | 0.992 |
| Hypertension (yes), n (%) | 63 (84) | 762 (90.1) | 88 (92.6) | 0.160 |
| Dyslipidaemia (yes), n (%) | 46 (61.3) | 543 (64.2) | 68 (71.6) | 0.296 |
| Stage 3 | 20 (26.7) | 233 (27.5) | 18 (18.9) | 0.429 |
| Stages 4 and 5 | 14 (18.7) | 185 (21.9) | 24 (25.3) | |
| Dialysis | 41 (54.7) | 428 (50.6) | 53 (55.8) | |
| Months in dialysis | 26.49 (25.96) | 27.59 (33.96) | 28.02 (28.18) | 0.961 |
| Type of dialysis (HD), n (%) | 28 (68.3) | 276 (64.5) | 33 (62.3) | 0.830 |
| Body mass index (kg/m2) | 27.45 (5.29) | 27.77 (5.29) | 27.95 (5.64) | 0.751 |
| Systolic blood pressure (mmHg) | 140.4 (19.62) | 142.3 (23.43) | 140.05 (20.94) | 0.719 |
| Diastolic blood pressure (mmHg) | 82.07(10.25) | 80.84 (12.75) | 82.09 (12.09) | 0.717 |
| Pulse pressure (mmHg) | 58.36 (15.7) | 61.52 (19.1) | 58 (17.76) | 0.308 |
| Haematocrit (%) | 38.27 (4.58) | 37.59 (5) | 37.68 (3.9) | 0.538 |
| Albumin (g/dL) | 3.95 (0.5) | 4.02 (0.44) | 4.06 (0.4) | 0.165 |
| iPTH (pg/mL) | 238.97 (232.18) | 211.71 (204.13) | 211.5 (182.86) | 0.590 |
| C-reactive protein | 4.53 (6.4) | 5 (9.35) | 3 (4.11) | 0.214 |
| Total cholesterol (mg/dL) | 175.16 (44.94) | 173.26 (39.83) | 174.46 (39.49) | 0.931 |
| High-density lipoprotein cholesterol (mg/dL) | 49.19(18) | 49.09 (16.1) | 48.65 (12.93) | 0.968 |
| Low-density lipoprotein cholesterol (mg/dL) | 95.96 (40.5) | 97.74 (33.6) | 98.07 (33.47) | 0.898 |
| Triglycerides (mg/dL) | 157.63 (107.56) | 139.26 (73.77) | 148 (71) | 0.162 |
| Glucose (mg/dL) | 101.46 (32.65) | 105.68 (41.52) | 113.04 (49.18) | 0.083 |
| Calcium (mg/dL) | 9.19 (0.75) | 9.23 (0.62) | 9.21 (0.57) | 0.9 |
| Phosphate (mg/dL) | 4.2 (1.34) | 4.34 (1.26) | 4.47 (1.32) | 0.250 |
| Sodium (mEq/L) | 139.43 (3.27) | 139.9 (3.29) | 139.72 (2.92) | 0.516 |
| Potassium (mEq/L) | 4.93 (0.65) | 4.83 (0.65) | 4.85 (0.62) | 0.496 |
| Any plaque basal (yes), n (%) | 47 (62.7) | 598 (70.7) | 73 (76.8) | 0.131 |
| Pathological ankle–brachial index (yes), n (%) | 19 (25.7) | 256 (30.6) | 36 (38.3) | 0.184 |
| Cardiovascular death (yes), n (%) | 3 (4) | 30 (3.5) | 1 (1.1) | 0.417 |
| Non-cardiovascular death (yes), n (%) | 10 (13.3) | 43 (5.1) | 2 (2.1) | 0.003 |
| Any death (yes), n (%) | 13 (17.3) | 73 (8.6) | 3 (3.2) | 0.005 |
Values are presented asaverage and SD unless stated otherwise. Comparisons between groups performed with ANOVA for quantitative variables and chi-squared test for categorical data. Statistically significant values are in bold. iPTH: intact parathyroid hormone.