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. 2020 Dec 21;2020:6406395. doi: 10.1155/2020/6406395

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Copyright © 2020 Jun-Xian Liang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Skin changes of SD rats after treatment with ADSC-derived exosomes. (a) HE staining showed the changes in epidermal and dermal thickness of SD rats exposed to UVB 28 d after ADSC-derived exosome treatment (×100). Ki67 immunostaining showed the proliferation of basal cells of SD rats exposed to UVB and those treated with ADSC-derived exosomes for 28 days (×100). (b) The thickness of the epidermis in the ADSC-derived exosome treatment group was less than that in the control group at 7 days, 14 days, and 28 days after treatment (p < 0.05), indicating that the ADSC-derived exosome treatment reduced the epidermal layer thickness of photoaged skin. (c) The thickness of the dermis in the ADSC-derived exosome treatment group was higher than that in the control group at 7 days, 14 days, and 28 days after treatment (p < 0.05), indicating that the ADSC-derived exosome treatment increased the dermal layer thickness of photoaged skin.