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. 2020 Dec 15;11:609237. doi: 10.3389/fmicb.2020.609237

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Copyright © 2020 Carrier, Ng Kwan Lim, Jeannotte and Massé.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Targeting of translational enhancers by sRNAs. (A) The manXYZ polycistronic transcript is dually regulated by two regions of the sRNA SgrS. SgrS interacts with the coding sequence of manX and recruits Hfq to block translation. The pairing site on manX presents a C/A-rich sequence that could be a translational enhancer. On the other hand, SgrS interacts with the 5′UTR of manY and masks a U-rich translational enhancer, hindering the translation of manY and manZ. (B) Schematic representation of sRNAs targeting translational enhancers (upper panel) or not (lower panel). Percentage of G/U of the full sRNA sequence is indicated under the sRNA name. The G/U content of the seed region (orange) is indicated on the sRNA drawing.