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. 2020 Dec 15;11:601237. doi: 10.3389/fphys.2020.601237

Figure 1.

Figure 1

Maximum variation triggered by the microinjection of muscimol into paraventricular nucleus (PVN) of the hypothalamus in terms of (A) mean arterial pressure (MAP) and (B) renal sympathetic nerve activity (rSNA) in the control, hypertensive (2K1C) and renal deafferented hypertensive (2K1C DAx) rats. *p < 0.05 in relation to the control group; +p < 0.05 in relation to the 2K1C group (one-way ANOVA followed by Tukey’s post hoc test). (C) Representative histological image: the arrow indicates the site of microinjection into the PVN. Scale bar = 100 μm. 3 V, third ventricle. (D) Diagram representing the effect of muscimol microinjected into the PVN in terms of pulsatile arterial pressure (PAP), MAP, and rSNA in the control, hypertensive (2K1C) and renal deafferented hypertensive (2K1C DAx) rats. Microinjection of muscimol into the PVN triggered a higher drop in MAP and rSNA in 2K1C rats and the renal deafferentation blunted these findings. Hexa, hexamethonium.