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. 2020 Dec 15;11:587443. doi: 10.3389/fimmu.2020.587443

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Copyright © 2020 Chen, Zhong, Zhang, Su and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The PPI network was constructed by STRING and Cytoscape. There were 87 nodes and 754 edges in the PPI network. Besides, two modules were recognized by MCODE in Cytoscape. Cluster 1 (score = 23.28) was the most powerful module containing 26 nodes and 291 edges. Cluster 2 (score = 6.889) consisted of 10 nodes and 31 edges. Molecules represented as a pink diamond in the circle with a blue background represents genes belonging to cluster 1, pink triangles in the circle with a purple background represent genes belonging to cluster 2, and genes in the white background do not belong to either cluster. HOXB3, KIR2DL4, GH1, EBI3 and GPR29 in pink graphics were predicted genes using interactions between submitted genes in the PPI network by Cytoscape, and other nodes were of submitted genes in the PPI network and showed interactions between multiple genes.