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. 2020 Dec 15;11:587443. doi: 10.3389/fimmu.2020.587443

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Copyright © 2020 Chen, Zhong, Zhang, Su and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Using Cytohubba, a plugin Cytoscape, the top 10 genes were identified as hub genes. This analysis revealed two key genes: IFN-γ and IL-6 in the cluster. All the gene nodes and edges were calculated. Molecules represented as pink diamonds in the circle with a blue background represented genes belonging to the cluster showing the top ten genes in the network by the Cytoscape plugin Cytohubba, and pink circles without a colored background represent genes not belonging to this cluster. HOXB3, KIR2DL4, GH1, EBI3 and GPR29 in pink graphics were predicted genes using interactions between submitted genes in the PPI network by Cytoscape, and other nodes were of submitted genes in the PPI network and showed interactions between multiple genes.