Figure 8.

Drug targeting the two genes, IFN-γ and IL-6, shown as pink circles. 48 drugs as the main therapeutic agents shown in triangles and expressed in different groups according to scores. Firstly, the triangle in green represented GLUCOSAMINE obtained five scores through the DGIdb analysis, and it was the most relevant drug. Secondly, triangles in purple, including FONTOLIZUMAB and SILTUXIMAB acquired four scores, and these were the second most relevant drugs. Thirdly, drugs with three scores were OLSALAZINE and GINSENG ASIAN as shown by dark blue triangles, and INTERFERON ALFA-2B shown as dark blue diamonds since Interferon Alfa-2B was able to target both of the two key genes. Moreover, most drugs obtained two scores and are shown as light blue triangles (the target drugs with scores can be seen in Supplementary Table S6 ). Lastly, eight drugs, including FUMARIC ACID, APREMILAST, VX-702, CDP-6038, SIRUKUMAB, OLOKIZUMAB, ELSILIMOMAB and PF-04236921, obtained one score and are shown as blue-grey triangles. The scores of 48 drugs identified by the DGIdb show the importance of drugs, with a higher score indicating greater importance.