Table 1.
The genes selected from eligible articles associated with VKH disease.
| Number | Gene Symbol | Description | Gene ID of NCBI | Described in the Uveogene database yes or not |
|---|---|---|---|---|
| 1 | DRB1 | RNA-binding protein 45 | 129831 | Not |
| 2 | C3 | complement C3 | 718 | Yes |
| 3 | FCRL3 | Fc receptor like 3 | 115352 | Yes |
| 4 | PDCD1/PD1 | programmed cell death 1 | 5133 | Yes |
| 5 | IL23R | interleukin 23 receptor | 149233 | Yes |
| 6 | HLA-DRA | major histocompatibility complex, class II, DR alpha | 3122 | Yes |
| 7 | HLA-DRB5 | major histocompatibility complex, class II, DR beta 5 | 3127 | Not |
| 8 | ADO | 2-aminoethanethiol dioxygenase | 84890 | Yes |
| 9 | ZNF365 | zinc finger protein 365 | 22891 | Not |
| 10 | EGR2 | early growth response 2 | 1959 | Not |
| 11 | SUMO4 | small ubiquitin like modifier 4 | 387082 | Yes |
| 12 | CYP2R1 | cytochrome P450 family 2 subfamily R member 1 | 120227 | Not |
| 13 | KIR 3DS1 | killer cell immunoglobulin like receptor, three Ig domains and short cytoplasmic tail 1 | 3813 | Not |
| 14 | KIR 2DS1 | killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 1 | 3806 | Not |
| 15 | KIR 2DS5 | killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 5 | 3810 | Not |
| 16 | KIR 3DL1 | killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1 | 3811 | Not |
| 17 | KIR B | killer- cell immunoglobulin- like receptor B | 3805 | Not |
| 18 | aKIR | akirin 2 | 55122 | Not |
| 19 | JAK1 | Janus kinase 1 | 3716 | Yes |
| 20 | JAK2 | Janus kinase 2 | 3717 | Yes |
| 21 | STAT3 | signal transducer and activator of transcription 3 | 6774 | Yes |
| 22 | MIR146A | microRNA 146a | 406938 | Yes |
| 23 | ETS1 | ETS proto-oncogene 1, transcription factor | 2113 | Yes |
| 24 | CFH | complement factor H | 3075 | Yes |
| 25 | KIAA1109 | KIAA1109 | 84162 | Yes |
| 26 | IL27 | interleukin 27 | 246778 | Yes |
| 27 | TGFBR3 | transforming growth factor beta receptor 3 | 7049 | Yes |
| 28 | CD40 | CD40 molecule | 958 | Yes |
| 29 | TLR9 | toll like receptor 9 | 54106 | Yes |
| 30 | NLRP1 | NLR family pyrin domain containing 1 | 22861 | Yes |
| 31 | CLEC16A | C-type lectin domain containing 16A | 23274 | Yes |
| 32 | PTPN22 | protein tyrosine phosphatase non-receptor type 22 | 26191 | Yes |
| 33 | IFN-γ/IFN Gamma | interferon gamma | 3458 | Yes |
| 34 | BACH2 | BTB domain and CNC homolog 2 | 60468 | Yes |
| 35 | C1orf141 | chromosome 1 open reading frame 141 | 400757 | Not |
| 36 | CTLA4 | cytotoxic T-lymphocyte associated protein 4 | 1493 | Yes |
| 37 | UBLCP1 | ubiquitin like domain containing CTD phosphatase 1 | 134510 | Yes |
| 38 | IL12B | interleukin 12B | 3593 | Not |
| 39 | C2 | complement C2 | 717 | Not |
| 40 | CFB | complement factor B | 629 | Yes |
| 41 | CFI | complement factor I | 3426 | Yes |
| 42 | IL17F | interleukin 17F | 112744 | Yes |
| 43 | IL12RB2 | interleukin 12 receptor subunit beta 2 | 3595 | Not |
| 44 | MCP-1/CCL2 | C-C motif chemokine ligand 2 | 6347 | Yes |
| 45 | CCR6 | C-C motif chemokine receptor 6 | 1235 | Yes |
| 46 | FGFR1OP | centrosomal protein 43 | 11116 | Yes |
| 47 | TNFAIP3 | TNF alpha induced protein 3 | 7128 | Yes |
| 48 | TRAF5 | TNF receptor associated factor 5 | 7188 | Yes |
| 49 | IL25 | Interleukin-25 | 64806 | Not |
| 50 | HLA-DRB4 | HLA class II histocompatibility antigen, DR beta 4 chain | 3126 | Not |
| 51 | IGHD | Immunoglobulin heavy constant delta | 3495 | Not |
| 52 | TGFBR2 | TGF-beta receptor type-2 | 7048 | Not |
| 53 | PSIP1 | PC4 and SFRS1-interacting protein | 11168 | Not |
| 54 | HLA-B | HLA class I histocompatibility antigen B alpha chain | 3106 | Not |
| 55 | UACA | Uveal autoantigen with coiled-coil domains and ankyrin repeats | 55075 | Not |
| 56 | PAPSS2 | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 | 9060 | Not |
| 57 | CXCL10 | C-X-C motif chemokine 10 | 3627 | Yes |
| 58 | CD4 | T-cell surface glycoprotein CD4 | 920 | Not |
| 59 | HLA-DPB1 | HLA class II histocompatibility antigen, DP beta 1 chain | 3115 | Not |
| 60 | TNFSF13 | Tumor necrosis factor ligand superfamily member 13 | 8741 | Not |
| 61 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 916 | Not |
| 62 | GPBAR1 | G-protein coupled bile acid receptor 1 | 151306 | Not |
| 63 | HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 | 3123 | Yes |
| 64 | BCL2A1 | Bcl-2-related protein A1 | 597 | Not |
| 65 | CXCL9 | C-X-C motif chemokine 9 | 4283 | Not |
| 66 | LEP | Leptin | 3952 | Not |
| 67 | AGER | Advanced glycosylation end product-specific receptor | 177 | Not |
| 68 | FAS | Tumor necrosis factor receptor superfamily member 6 | 355 | Not |
| 69 | IL35 | Interleukin-35 | 3592 | Not |
| 70 | TYR | Tyrosinase | 7299 | Not |
| 71 | IL23A | Interleukin-23 subunit alpha | 51561 | Not |
| 72 | HLA-DQA1 | HLA class II histocompatibility antigen, DQ alpha 1 chain | 3117 | Not |
| 73 | ARMC9 | armadillo repeat containing 9 | 80210 | Not |
| 74 | IL9 | Interleukin-9 | 3578 | Not |
| 75 | C4B | Complement C4-B | 721 | Not |
| 76 | IL21 | Interleukin-21 | 59067 | Not |
| 77 | IL6 | Interleukin-6 | 3569 | Not |
| 78 | C3AR1 | C3a anaphylatoxin chemotactic receptor | 719 | Not |
| 79 | IL2RA | Interleukin-2 receptor subunit alpha | 3559 | Not |
| 80 | CCL8 | C-C motif chemokine 8 | 6355 | Not |
| 81 | DAB2 | Disabled homolog 2 | 1601 | Not |
| 82 | KIR2DS3 | Killer cell immunoglobulin-like receptor 2DS3 | 3808 | Not |
| 83 | SPP1 | Osteopontin | 6696 | Yes |
| 84 | NOD1 | Nucleotide-binding oligomerization domain-containing protein 1 | 10392 | Not |
| 85 | IL37 | Interleukin-37 | 27178 | Not |
| 86 | HLA-DQB1 | HLA class II histocompatibility antigen, DQ beta 1 chain | 3119 | Not |
| 87 | FOXP3 | Forkhead box protein P3 | 50943 | Not |
| 88 | IL7 | Interleukin-7 | 3574 | Not |
| 89 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | 3654 | Not |
| 90 | HLA-A | MHC class I antigen | 3105 | Not |
| 91 | IL4 | Interleukin-4 | 3565 | Not |
| 92 | MIF | Macrophage migration inhibitory factor | 4282 | Not |
| 93 | TLR3 | Toll-like receptor 3 | 7098 | Not |
| 94 | KIR2DS2 | Killer cell immunoglobulin-like receptor 2DS2 | 100132285 | Not |
| 95 | VEGFA | Vascular endothelial growth factor A | 7422 | Not |
| 96 | ESD | S-formylglutathione hydrolase | 2098 | Not |
| 97 | CXCL1 | C-X-C motif chemokine ligand 1 | 2919 | Not |
| 98 | FCGBP | Fc fragment of IgG binding protein | 8857 | Not |
| 99 | PAX3 | Paired box 3 | 5077 | Not |
| 100 | CXCL13 | C-X-C motif chemokine 13 | 10563 | Not |
| 101 | IL15 | Interleukin-15 | 3600 | Not |
| 102 | IL1B | Interleukin-1 beta | 3553 | Not |