Figure 2.

Higher anxiety levels were observed in iTat mice compared to Treatment Time WT controls in elevated plus maze testing. Anxiety levels were measured by (A) the percent time spent in the open arms and (B) total distance covered on the maze in iTat and WT mice. The WT mice (n = 6, open circles) and the iTat mice (n = 12, open squares) received acute induction by DOX i.p. injections, while the WT mice (n = 13, solid circles) and the iTat mice (n = 13, solid squares) received prolonged induction via DOX food. Each bar represents the mean ± SEM. *p < 0.050 for same Treatment Time comparisons between Strains by two-way ANOVA using Treatment Time and Strain as variables.