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. 2020 Dec 15;11:593188. doi: 10.3389/fneur.2020.593188

Figure 5.

Figure 5

Prolonged HIV-1 Tat expression increased trials to reach avoidance criteria in iTat mice in discrimination reversal test. The T-maze test measured the number of total trials taken by iTat and WT mice to reach discriminated avoidance criteria during three sessions. The WT mice (n = 7, open circles) and the iTat mice (n = 11, open squares) received acute induction by DOX i.p. injections, while the WT mice (n = 12, solid circles) and the iTat mice (n = 13, solid squares) received prolonged induction via DOX food. Each bar represents the mean ± SEM, TTC: total trials to criteria, TTC1: Acquisition session, TTC2, TTC3: Reversal session, *p < 0.050 for same Treatment Time comparisons between Strains, #p < 0.050 for same Strain comparisons across Treatment Time by two-way ANOVA using Treatment Time and Strain as variables.