Figure 7.

Acute vs. prolonged HIV-1 Tat induction dysregulated MMP/TIMP balance in iTat mice. (A) TIMP-1, (B) TIMP-2, (C) MMP-9, (D) and MMP-2 gene expression was measured in iTat and WT mice. The WT mice (n = 7, open circles) and the iTat mice (n = 11, open squares) received acute induction by DOX i.p. injections, while the WT mice (n = 12–13, solid circles) and the iTat mice (n = 12 – 13, solid squares) received prolonged induction via DOX food. Each bar represents the mean ± SEM, *p < 0.050 same Treatment Time comparisons between Strains, ^#p < 0.050 for the same Strain comparisons across the treatments by two-way ANOVA using Treatment Time and Strain as variables.