Table 3.
Comparing characteristics of patients who developed lupus nephritis within the first 2 years of diagnosis by baseline autoimmune cytopenia status.
| Characteristics | All cSLE* | cSLE with AC | cSLE without AC* |
|---|---|---|---|
| (n = 16) | (n = 3) | (n =13) | |
| N (%) | N (%) | N (%) | |
| LN by classa | |||
| II | 3/15 (20) | 0/3 (0) | 3/12 (25) |
| III | 2/15 (13) | 0/3 (0) | 2/12 (17) |
| IV | 5/15 (33) | 1/3 (33) | 4/12 (33) |
| V | 3/15 (20) | 2/3 (67) | 1/12 (8) |
| IV/V | 2/15 (13) | 0/3 (0) | 2/12 (17) |
| LN severitya | |||
| Mild i.e. Class I and II only | 3/15 (20) | 0/3 (0) | 3/12 (25) |
| Renal characteristics at time of LN diagnosis | |||
| eGFR < 90mL/min/1.73m2a | 6/15 (40) | 1/3 (33) | 5/12 (42) |
| UPCr ≥2 mg/mga | 10/16 (63) | 3/3 (100) | 7/13 (54) |
| RBC casts at time of LN diagnosisa | 1/16 (6) | 0/13 (0) | 1/13 (8) |
| Hematuria >5RBC/hpfa | 12/16 (75) | 1/3 (33) | 11/13 (85) |
| Interval of LN from time of cSLE diagnosis in months | |||
| >1 to ≤ 6 | 6/16 (38) | 1/3 (33) | 5/13 (39) |
| > 6 to ≤ 12 | 3/16 (19) | 0/3 (0) | 3/13 (23) |
| > 12 to ≤ 24 | 7/16 (44) | 2/3 (67) | 5/13 (39) |
Abbreviations: AC = Autoimmune cytopenia; cSLE = Childhood-onset systemic lupus erythematosus; eGFR= Estimated glomerular filtration rate; LN= Lupus nephritis; UPCr = Urine protein to creatinine ratio
a
Fisher’s exact test
*
Missing 1 patient without kidney biopsy