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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Bone. 2020 Sep 26;143:115663. doi: 10.1016/j.bone.2020.115663

Table 3.

Key questions about LCS remodeling and future directions for research.

Key questions Future directions
Does LCS participate in bone mineralization? •How does the LCS affect primary and secondary mineralization?
• Do mineral gradients near the LCS reflect tissue maturation?
• How is mineralization around the LCS affected by aging and disease?
How does altered LCS remodeling affect bone quality and tissue through whole-bone length-scales? •Does the frequency of LCS remodeling change in health and with aging and disease?
• Does tissue composition and mechanical properties vary between remodeling and non-remodeling lacunae and canaliculi?
• Does LCS remodeling affect mineral and collagen turnover around individual osteocytes?
• How are tissue toughening mechanisms are impacted by LCS remodeling?
How should tissue composition and mechanical properties be assessed near the LCS? •Do insufficiently high-resolution techniques result in ‘false negatives’ about material property gradation near the LCS?
• How many lacunae/canaliculi per sample should be assessed to generalize LCS remodeling phenotype?