Table 3.

Magnetic resonance spectroscopy results by randomized group and outcome at hospital discharge.

	Overall N=14	24 hr hypothermia N=8	72 hr hypothermia N=6	p	Favorable outcome N=6	Unfavorable outcome N=8	p
Basal Ganglia
Lactate	1.18 (0.89–2.03)	1.67 (1.07–3.29)	0.96 (0.47–1.19)	0.181	0.75 (0.21–1.41)	1.56 (1.07–4.47)	0.108
N-acetylaspartate	6.99 (4.49–8.21)	6.99 (4.24–7.74)	7.48 (4.85–9.13)	0.414	8.36 (7.29–9.13)	5.60 (4.09–7.04)	0.059
Lactate/NAA Ratio	0.19 (0.10–0.35)	0.27 (0.15–0.68)	0.14 (0.05–0.19)	0.282	0.08 (0.03–0.28)	0.23 (0.18–1.10)	0.081
Parietooccipital gray matter
Lactate	0.93 (0.69–1.98)	1.53 (0.81–2.68)	0.82 (0.63–0.92)	0.108	0.74 (0.68–0.92)	1.83 (0.90–2.68)	0.043
N-acetylaspartate	4.82 (3.42–8.86)	3.81 (3.03–7.79)	6.90 (4.70–10.85)	0.228	9.73 (7.88–10.85)	3.54 (2.52–4.82)	0.005
Lactate/NAA Ratio	0.16 (0.09–0.83)	0.40 (0.10–0.93)	0.11 (0.09–0.18)	0.228	0.09 (0.06–0.09)	0.64 (0.16–0.93)	0.005
Parietal white matter
Lactate	0.99 (0.70–1.78); n=9	1.06 (0.67–1.58); n=4	0.99 (0.70–1.78); n=5	0.905	0.74 (0.64–1.27); n=4	1.35 (0.99–1.81); n=5	0.286
N-acetylaspartate	8.07 (6.81–9.10); n=9	8.07 (7.44–8.82); n=4	7.50 (4.62–9.10); n=5	0.730	9.33 (8.58–10.10); n=4	6.81 (4.62–7.50); n=5	0.032
Lactate/NAA Ratio	0.20 (0.08–0.23); n=9	0.14 (0.08–0.21); n=4	0.20 (0.09–0.30); n=5	0.730	0.08 (0.07–0.14); n=4	0.23 (0.20–0.30); n=5	0.032
Thalamus
Lactate	1.31 (0.97–1.95); n=13	1.35 (0.97–2.66); n=7	1.15 (0.72–1.95); n=6	0.534	1.10 (0.54–1.95)	1.35 (1.07–4.23); n=7	0.295
N-acetylaspartate	8.12 (6.20–9.77)	8.12 (6.20–10.20)	8.30 (6.19–9.77)	0.945	9.69 (8.12–10.20)	6.97 (4.16–9.76)	0.138
Lactate/NAA Ratio	0.16 (0.12–0.20)	0.16 (0.12–0.43)	0.15 (0.10–0.20)	0.836	0.12 (0.05–0.20)	0.17 (0.13–1.02)	0.295

Comparisons between metabolites and randomized or outcome group analyzed with Wilcoxon rank sum test

NAA, N-acetyl-aspartate