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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2020 Nov 5;41(1):346–359. doi: 10.1161/ATVBAHA.120.315472

Figure 4. RNA sequence analysis with HDMVECs in response to septin 2 suppression and TNF-α treatment.

Figure 4.

(A) Principal component analysis (PCA) of septin 2-suppressed and TNF-α-treated HDMVECs. PCA was performed with all genes. (B) Volcano plot of septin 2 suppression compared to control highlights differentially expressed genes using a fold-change > 2 as the cut-off value. (C) Volcano plot of TNF-α treatment compared to no treatment highlights differentially expressed genes using a fold-change > 2 as the cut-off value. Selected over-represented GO terms associated with various biological processes (D-E), cell-cell adhesion processes (F-G) and absolute fold-change > or <2 (H-l). Septin 2 suppression is compared to control, and TNF-α treatment is compared to no treatment.