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. 2020 Dec 15;11:615972. doi: 10.3389/fphar.2020.615972

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Copyright © 2020 Han, Guo, Zheng, Zhang, De, Xu, Zhang, Sun, Lv, Liang, Xu, Pang and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pooled odds ratio and forest plot of mortality between the anti-IL-6 signaling treatment and standard of care (SOC) groups among patients with COVID-19. Thirty-one studies including 5,630 patients with COVID-19 were included in the statistical analysis, with 2,132 treated patients and 3,498 controls. The result showed that anti-IL-6 signaling agents plus SOC significantly decreased mortality relative to SOC alone in patients with COVID-19 (pooled OR = 0.61, 95% CI 0.45–0.84, p = 0.002).