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. 2020 Dec 15;11:615972. doi: 10.3389/fphar.2020.615972

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Copyright © 2020 Han, Guo, Zheng, Zhang, De, Xu, Zhang, Sun, Lv, Liang, Xu, Pang and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pooled odds ratio and forest plot of secondary infections between the anti-IL-6 signaling treatment group and standard of care group in patients with COVID-19. Twelve studies were included in the statistical analysis on secondary infections, including 639 patients treated with IL-6 signaling inhibitors and 985 patients with SOC. There was no significant difference in terms of secondary infection rates between patients with COVID-19 treated with anti-IL-6 signaling agents and those treated with SOC (pooled OR = 1.21, 95% CI 0.70–2.08, p = 0.50).