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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2020 Oct 29;41(1):458–464. doi: 10.1161/ATVBAHA.120.314965

Table 1:

Association of lead variants with Lp(a).

Variant CHR Position Genes in Locus Minor Allele (Freq) β [95% CI] ((ln nmol/L) P Variants in Locus*
rs10455872 6 161010118 LPA, ZDHHC14, SNX9† G (0.076) 1.7 [1.7,1.7] 6.2 × 10−22,136 127
rs1065853 19 45413233 APOE T (0.080) −0.11 [−0.12, −0.10] 2.8 × 10−96 1
rs247617 16 56990716 CETP A (0.32) −0.023 [−0.030, −0.017] 1.0 × 10−13 1
rs8178824 17 64224775 APOH T (0.030) 0.064 [0.047,0.081] 2.8 × 10−13 1
rs826128 2 184797074 AC093639.1 A (0.054) −0.039 [−0.053, −0.026] 5.9 × 10−9 1
*

Number of independent (r2 < 0.01), genome-wide significant variants.

†

Additional genes (+/− 3.5 MB from LPA): TULP4, SYTL3, EZR, RP1-155D22.1, RSPH3, RP1-111C20.4, FNDC1, RP11-125D12.1, RP11-125D12.2, RP3-393E18.1, SOD2, ACAT2, PNLDC1, RP1-249F5.3, IGF2R, SLC22A1, SLC22A2, SLC22A3, LPAL2, PLG, RP11-235G24.1, RP11-235G24.2, RP11-235G24.3, RP3-428L16.1, MAP3K4, AGPAT4, PARK2.