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. 2020 Dec 28;10:22391. doi: 10.1038/s41598-020-79495-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Exemplary patients. The paraspinal skeletal muscle area at the level of the superior mesenteric artery was separated into areas of fatty and lean muscle based on attenuation threshold ranges from CT scans around 4 days of ECMO implantation for acute respiratory failure. FMF was calculated at the fatty muscle area related to the total skeletal muscle area. Based on median FMF of the entire study population (n = 87), patients were binarized with a cutoff value of > 44% to define high FMF. Panels show exemplary patients with high and low FMF with corresponding 1-year mortality rates. CT computed tomography, ECMO Extracorporeal membrane oxygenation, FMF Fatty muscle fraction.