Table 1.
Clinical characteristics of the study population.
| Variable | High FMF (N = 44) | Low FMF (N = 43) | P value | Test value | |
|---|---|---|---|---|---|
| Age (years) | 57 ± 12 | 50 ± 14 | 0.014 | t = 2.498 | |
| Sex (male) | 25 (57%) | 33 (77%) | 0.049 | χ2 = 3.886 | |
| Body Mass Index (kg/m2) | 30.9 (25.7–38.1) | 26.6 (23.7–31.8) | 0.018 | U = 619 | |
| Total skeletal muscle compartment area (cm2) | 51.3 ± 14.8 | 48.0 ± 13.4 | 0.275 | t = 1.098 | |
| Skeletal muscle area (cm2) | 43.3 ± 11.3 | 44.9 ± 12.4 | 0.530 | t = 0.630 | |
| Skeletal muscle index (cm2/m2) | 25.0 ± 5.9 | 25.5 ± 6.4 | 0.758 | t = 0.309 | |
| Muscle mean attenuation (HU) | 17.9 ± 8.2 | 36.1 ± 7.5 | < 0.001 | U = 40 | |
| Pre-ECMO cardiopulmonary resuscitation | 5 (11%) | 9 (21%) | 0.206 | χ2 = 1.597 | |
| Pre-ECMO renal failure (CRRT) | 24 (62%) | 12 (29%) | 0.003 | χ2 = 8.901 | |
| Charlson comorbidity index | 2 (1–3) | 2 (1–3) | 0.798 | U = 916 | |
| Simplified acute physiology score II | 47.0 ± 12.8 | 43.2 ± 13.0 | 0.208 | t = 1.269 | |
| Diagnosis (pulmonary acute respiratory distress syndrome) | 27 (61%) | 26 (61%) | 0.931 | χ2 = 0.007 | |
| Days on mechanical ventilation prior initiation of ECMO support | < 2 | 20 (46%) | 26 (60%) | 0.161 | χ2 = 1.966 |
| 2–7 | 16 (36%) | 13 (30%) | 0.544 | χ2 = 0.368 | |
| > 7 | 8 (18%) | 4 (9%) | 0.230 | χ2 = 1.442 | |
| Respiratory ECMO survival prediction (RESP) score (%) | 45 (35–50) | 55 (40–75) | 0.011 | U = 633 | |
| Duration of ECMO support (days) | 12.5 (8.0–18.0) | 9.0 (7.0–16.0) | 0.266 | U = 814.5 | |
| Weaning from ECMO | 20 (46%) | 30 (70%) | 0.022 | χ2 = 5.259 | |
The cohort was binarized into patients with high and low FMF with a cutoff value of > 44% to define high FMF. Continuous variables are expressed as means with standard deviation while categorical variables are given as total counts and percentages. CRRT Continuous Renal Replacement Therapy, ECMO Extracorporal Membrane Oxygenation, FMF Fatty muscle fraction, RESP Respiratory ECMO Survival Prediction Score.