Table 2.

Multivariable risk factor analysis for 1-year mortality.

Variable	P value	Hazard ratio (95% CI)
Age	0.430	1.013 (0.981–1.047)
Sex	0.358	1.388 (0.690–2.791)
Body Mass Index	0.339	0.984 (0.952–1.017)
Charlson comorbidity index	0.732	0.975 (0.845–1.126)
Respiratory ECMO survival prediction score (%)	0.080	0.979 (0.955–1.033)
Duration of ECMO support	0.583	1.007 (0.982–1.033)
Simplified acute physiology score II	0.570	1.010 (0.977–1.043)
FMF percent	0.031	1.017 (1.002–1.033)

A multivariable logistic regression model was built to test the impact of clinical variables on 1-year mortality. FMF was included as a continuous variable alongside with a set of a priori selected covariates, which were judged reasonable based on previous literature and clinical perception. Results are displayed as adjusted hazard ratio (HR) with 95% confidence interval (CI). The level of statistical significance was set to P < 0.05. In this analysis, FMF was identified as a risk factor for 1-year mortality following ECMO, independent of anthropometric parameters (age, sex, BMI), duration of ECMO support, severe systemic comorbidities (Charlson comorbidity index), severity of disease (Simplified Acute Physiology Score II), and clinical risk stratification (Respiratory ECMO Survival Prediction Score). ECMO Extracorporal Membrane Oxygenation, FMF Fatty Muscle Fraction.