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. 2020 Dec 28;10:22385. doi: 10.1038/s41598-020-79374-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Comprehensive and longitudinal behavioral phenotyping after repeated administration of clinical doses of linear gadodiamide and macrocyclic gadobutrol in a rat model. (a) Experimental setup for longitudinal and comprehensive behavioral phenotyping from 5 to 30 weeks after the last injection showing time points of the behavioral tests. (b) Representative images from T1-weighted (T1w) MRI at 4.7 T in axial orientation 5 weeks p.i. Regions of interest in the lateral cerebellar nuclei are marked by arrows (left panel). Spatial distribution and quantification of Gd in the cerebellum at 11 weeks p.i. (middle panel). Macroscopic NSF-like skin lesions in gadodiamide rats observed until 12 weeks p.i. (right panel).