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. 2020 Dec 28;10:22385. doi: 10.1038/s41598-020-79374-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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No alterations in number of NeuN-positive cells and gene expression as well as overlap of aggrecan and Gd distribution in the lateral cerebellar nucleus. (a) Numbers of NeuN-positive cells in the lateral cerebellar nucleus and adjacent deep cerebellar nuclei of treated and control animals 11 weeks p.i. determined by stereological analysis. (b) Gene expression pathway analysis in the lateral cerebellar nucleus, globus pallidus and somatosensory cortex (control region) 11 weeks p.i. (c) Conventional immunohistochemistry of aggrecan in the cerebellum of animals sacrificed 11 weeks p.i. (left panel, scale bar: 500 µm). Distribution of Gd and aggrecan in the cerebellum of animals sacrificed 5 weeks p.i. by immunohistological LA-ICP-MS (right panel). Representative pseudo-colored overlays of Gd (red), aggrecan (green) and an iridium containing nucleic acid intercalator (blue) at different magnification. Fields of higher magnification are indicated by squares. Data represent mean ± SEM; n is indicated in the columns.