. Author manuscript; available in PMC: 2022 Jan 1.

Published in final edited form as: J Surg Oncol. 2020 Nov 12;123(1):42–51. doi: 10.1002/jso.26253

Table 3.

Multivariate Cox regression model analyses of Overall survival, Recurrence free survival and Disease specific survival with PRL3 staining as continuous variable

Parameters		Overall survival (OS)		Recurrence free survival (RFS)		Disease specific survival (DSS)

		HR (95% CL)	p-value	HR (95% CL)	p-value	HR (95%CL)	p-value

PRL3 Staining	1 unit increase	1.00 (0.99 – 1.02)	0.56	1.00 (0.99 – 1.01)	0.69	1.00 (0.99 – 1.02)	0.76

Age	≥ 65	1.44 (0.94 – 2.21)	0.094
Age	< 65	1

Stage	III/IV	2.75 (1.99 – 3.80)	<0.0001	2.92 (2.16 – 3.95)	<0.0001	10.50 (6.30 – 17.49)	<0.0001
Stage	I/II	1		1		1

Blood/lymphatic vessel invasion	Intramural vessel	1.85 (0.93 – 3.69)	0.051	2.02 (1.01 – 4.05)	0.026	2.41 (1.06 – 5.45)	0.0024
	Extramural vessel	2.42 (0.91 – 6.41)		2.93 (0.99 – 8.68)		2.60 (1.01 – 6.72)
	Absent	1		1		1