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. 2020 Dec 29;6:95. doi: 10.1038/s41421-020-00218-1

Fig. 6. The genome organizations of integrated HBV DNA with human chromosomes.

Fig. 6

a, b Top: 3C-HTGTS interaction profiles of the integrated HBV DNA in HepAD38 cells with DOX and HepG2-NTCP cells infected by HBV. In chromosome 2 (a) or chromosome 21 (b). #1 using primer 1 datasets, #2 using primer 2 datasets visualization with UCSC Genome Browser (we used vertical viewing range setting for sequencing data display). Middle: the genes and promoters in that locale regions (promoter regions from GeneHancer Track of UCSC Genome Browser). Bottom: schematic representation of chromosome interactions of the integrated HBV DNAs with Human DNAs. c, d UCSC Genome Browser track showing integrated HBV DNA–host DNA contacts (using HepAD38 #2 3C-HTGTS sample), H3K27ac, H3K4me1, H3K9ac, and H3K9me3. The ChIP-seq data were from the ENCODE, generated by Bradley Laboratory, which were used HepG2 cells (we used vertical viewing range setting for sequencing data display).