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. Author manuscript; available in PMC: 2021 Dec 24.
Published in final edited form as: J Med Chem. 2020 Dec 7;63(24):15883–15905. doi: 10.1021/acs.jmedchem.0c01609

Table 7.

MEK1/2 Degradation Potencies of Compound 50a

cell line target protein DC50 (nM)
HT-29 MEK1 118 ± 23
MEK2 55 ± 19
SK-MEL-28 MEK1 94 ± 3
MEK2 38 ± 15
a

DC50 values are presented as the mean ± SD from three independent experiments.