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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Biochim Biophys Acta Proteins Proteom. 2020 Oct 29;1869(2):140558. doi: 10.1016/j.bbapap.2020.140558

Figure 2:

Figure 2:

The AAA proteases are organized in a higher order complex. i-AAA faces the intramembrane space and can interact with SLP2 and PARL on the opposite site of the inner membrane (IM). m-AAA on the matrix side can interact with the prohibitins (PHB1 and PHB2) and presumably OMA1 on the intramembrane space-facing side of the IM. Genetic alterations of any of these members of the AAA protein complex impact OMA1 function.