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. 2021 May;11(5):a034892. doi: 10.1101/cshperspect.a034892

Figure 3.

Figure 3.

Summary of the diverse kinase mutations in histiocytic neoplasms. (A) Protein diagrams cataloging the published somatic mutations described in the RAF isoforms (BRAF, ARAF, and RAF1 [CRAF]). (B) Protein diagrams cataloging the somatic mutations discovered in MEK1 and MEK2. (C) Protein diagrams cataloging the somatic mutations uncovered in the RAS isoforms (KRAS and NRAS). (D) Protein diagrams cataloging somatic mutations described in ERK1, ERK2, and ERK5. (E) Protein diagrams cataloging somatic mutations involving the PI3K isoforms (PIK3CA and PIK3CD). (F) Protein diagrams documenting somatic mutations recently discovered in the receptor tyrosine kinases. (G) Protein diagram cataloging somatic mutations in CSF3R. LCH, Langerhans cell histiocytosis; ECD, Erdheim–Chester disease; JXG/AXG, juvenile xanthogranuloma/adult xanthogranuloma; RDD, Rosai–Dorfman–Destombes disease; ICH, indeterminate cell histiocytosis.