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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2020 Oct 29;41(1):20–34. doi: 10.1161/ATVBAHA.120.313791

Figure 2. Runx2 interaction with various cytosolic and nuclear proteins that regulate its post-translational modification, cellular localization and stability, and transcriptional activity.

Figure 2.

The binding proteins of the Runt-related transcription factor 2 (Runx2) regulate Runx2 posttranslational modifications (PTMs), including phosphorylation, ubiquitination, acetylation and O-GlcNAcylation are shown (top left); Runx2 nuclear translocation, DNA binding and transcriptional activities are highlighted (top right). The key regulators for Runx2 PTMs and Runx2 transactivity are shown in the respective box. In addition, binding of Runx2 to the CBF consensus sequence TGT/cGGT on the target genes, via its Runt-homology domain, regulates the transcription of the target genes (bottom).