Table 1.

Cortical bone parameters measured from the distal 1/3 femur and mechanics properties from 3-pt-bend test of the contralateral femur of adenine-induced CKD mice. Group values not sharing the same superscript letters are statistically different (p<0.05 from a Student’s t-test for 10-week values and from a Duncan post-hoc following a 2X3 ANOVA for 14-week data). Group values without letters have no statistical differences.

	Cortical Bone Area (mm²)	Cortical Thickness (mm)	Pore Number (#/mm²)	Ultimate Force (N)	Postyield Displacement (μm)	Stiffness (N/mm)	Total Work (mJ)	Toughness (Mpa)
*10-week*
*Control*	0.68 ± 0.06	0.14 ± 0.01^a	0.08 ± 0.1^a	18.10 ± 1.91^a	269 ± 142	75.28 ± 5.33	6.05 ± 1.82	2.20 ± 0.81
*Adenine*	0.69 ± 0.03	0.12 ± 0.01^b	1.06 ± 0.71^b	16.19 ± 2.26^b	242 ± 106	69.78 ± 7.27	4.89 ± 1.17	2.05 ± 0.53
*14-week*
*Control*	0.69 ± 0.40	0.14 ± 0.01^ab	0.03 ± 0.04^a	17.92 ± 0.94^b	298 ± 19	82.37 ± 5.38^ab	6.26 ± 1.83^a	2.18 ± 0.70
*Con+1.5%*	0.70 ± 0.56	0.15 ± 0.01^a	0.03 ± 0.03^a	18.67 ± 2.21^ab	265 ± 190	82.34 ± 6.99^ab	5.78 ± 1.81^a	2.13 ± 0.44
*Con+3%*	0.74 ± 0.05	0.16 ± 0.01^a	0.04 ± 0.03^a	20.62 ± 1.80^a	180 ± 93	88.34 ± 7.83^a	5.78 ± 1.16^a	1.87 ± 0.38
*Adenine*	0.66 ± 0.09	0.11 ± 0.01^d	0.94 ± 0.58^c	15.83 ± 2.69^c	232 ± 196	74.71 ± 6.63^b	4.32 ± 1.54^b	1.77 ± 0.71
*Ad+1.5%*	0.65 ± 0.21	0.13 ± 0.03^c	0.33 ± 0.25^b	18.74 ± 3.46^ab	204 ± 53	78.63 ± 12.43^b	5.14 ± 0.79^ab	1.93 ± 0.42
*Ad+3%*	0.70 ± 0.07	0.13 ± 0.01^bc	0.17 ± 0.10^ab	18.10 ± 1.52^b	244 ± 74	79.75 ± 7.38^b	5.32 ± 1.24^ab	1.96 ± 0.35