Figure 2.

Preparatory activity mediated by the cortico-cerebellar loop. A. Discrete states in activity space correspond to specific movements. Preparatory activity trajectories converge to specific states during motor planning. Once the state is reached, the corresponding movement can be readily triggered. When the trajectory transitions to a different state, a different movement will result. B. Left, mouse navigating a virtual reality and anticipating reward at a particular location in the corridor indicated by visual landmarks. Middle, silicon probe recordings in ALM and the cerebellar nucleus while photoinhibiting the deep cerebellar nucleus. Right, preparatory activity in ALM neurons anticipates the stop which is abolished by silencing the cerebellar output [14]. C. Mouse performing a delayed response task. ALM preparatory activity anticipates directional licking which is abolished by silencing the cerebellar output [15].