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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Stroke. 2020 Nov 9;52(1):274–283. doi: 10.1161/STROKEAHA.120.032766

Figure 4. Partial inhibition of CSD-induced calcium transients in microglia with selective CRAC channel blocker CM-EX-137.

Figure 4.

A, Mice received 25 mg/kg CM-EX-137, or vehicle, in 200 μL p.o. The mean peak intensity of calcium transients during KCl-evoked CSD was reduced by 20% in the CM-EX-137 treated animals. B, The average duration of calcium transients tended to be shorter in the animals receiving drug (14.89 s vs.16.39 s in controls), but the difference was not statistically significant. C, The mean area under the curve calculated from the GCaMP5 fluorescence peaks was found to be significantly reduced by 26% (p = 0.012, unpaired two-tailed t-test. n=26 cells from 3 mice for vehicle controls; n=30 cells from 3 animals for drug treated mice, in all panels). Horizontal lines in scatter plots indicate means ± SD.