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. Author manuscript; available in PMC: 2022 Jan 8.
Published in final edited form as: J Mol Biol. 2020 Jun 29;433(1):166584. doi: 10.1016/j.jmb.2020.06.023

Figure 5. BDL promote immune tolerance by inducing Treg proliferation via GITRL.

Figure 5.

BDL are a unique splenic B cell subset that expresses IgM, but not IgD, and interact with Treg via GITRL leading to their proliferation through engagement of GITR. A balance between BDL and Treg is required to maintain Treg numbers at a sufficient level to maintain a high level of immune tolerance leading to recovery from EAE. If BDL are depleted by anti-CD20, Treg numbers are reduced leading to reduced immune tolerance and chronic EAE.