Figure 3: Mapping of the binding epitope of AB2 using XFMS.
A. Dose-response graphs of the four residues with highest dkfp for AB2-uPA complex (red) and native uPA (black). Oxidation of His99 and His100 was detected on the same peptide. B. Residues from 3A (pink) mapped to structure of uPA and residues forming the catalytic triad (red).