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. 2020 Dec 15;14:605312. doi: 10.3389/fncel.2020.605312

Figure 4.

Figure 4

Streptozotocin-induced diabetes is accompanied with thermal and mechanical hypersensitivity in WT mice. (A) Experimental protocol for injection of STZ and time points of measurement of threshold to thermal and mechanical stimuli. (B) Time course of the development of hyperglycemia in mice after STZ injection (n = 10). (C) Changes in body weight of mice injected with STZ (n = 10, One way RM ANOVA, p = 0.244). (D) Time course of the development of hypersensitivity to thermal stimulus in mice after STZ injection (n = 10, Two-way RM ANOVA, treatment factor significant p < 0.001; F(3.28) = 24.54; Tukey post-hoc test: *p < 0.05; **p < 0.01; ***p < 0.001). (E) Time course of the development of hypersensitivity to mechanical stimulus in mice after STZ injection (n = 10, Two-way RM ANOVA, treatment factor significant p < 0.001; F(3,28) = 30.14; Tukey post-hoc test: **p < 0.01; ***p < 0.001).