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. 2020 Dec 15;11:579206. doi: 10.3389/fphar.2020.579206

FIGURE 7.

FIGURE 7

Effect of escitalopram (10 mg/kg/day; p. o., for 4 weeks) on histological damage in HFFD/STZ type 2 diabetic rats. (A–D) Specimens stained with H&E (magnification x200). Normal (A) and escitalopram (B) groups showed normal histological structure of regular cardiomyocytes with normal interstitium. HFFD/STZ diabetes group (C) showed showed irregular cardiomyocytes with cytoplasmic vacuolation (narrow arrow), loss of cardiomyocytes striations, focal coagulative necrosis (thick arrow) and marked interstitial edema with inflammatory cellular response (dashed arrow). Diabetes + escitalopram group (D) revealed relatively regular cardiomyocytes with mild interstitial edema and inflammatory infiltrate (dashed arrow). Myocardial score of damage expressed as median (interquartile changes) (E). Each value represents the median value [interquartile range]. Statistical analysis was done using non-parametric One-Way ANOVA followed by Dunn's multiple comparison test.*p < 0.05 vs. normal, # p < 0.05 vs. diabetes.