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. 2020 Dec 15;11:579206. doi: 10.3389/fphar.2020.579206

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Copyright © 2020 Ahmed, Shiha and Attia

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GRAPHICAL ABSTRACT — Escitalopram alleviates HFFD/STZ-induced metabolic and cardiac derangements in type 2 diabetic rats. BG: blood glucose, BW: body weight, ECG: electrocardiographic, HFFD: high fat-high fructose diet, HOMA-IR: homeostasis model assessment of insulin resistance, HR: heart rate, MHC: myosin heavy chain, NADPH oxidase: nicotinamide adenine dinucleotide phosphate oxidase, NF-κB: nuclear factor-kappa B, RAGE: receptor for advanced glycation end products, STZ: streptozotocin, TAC: total antioxidant capacity, TC: total cholesterol, TGF-β: transforming growth factor-beta, TGs: triglycerides, TNF-α: tumor necrosis factor-alpha.