TABLE 4.
Effect of escitalopram (10 mg/kg/day; p.o., for 4 weeks) on body weight, heart weight index, and electrocardiographic changes in HFFD/STZ type 2 diabetic rats.
| Groups | BW (g) | HWI (mg/g) | Electrocardiographic changes | ||
|---|---|---|---|---|---|
| HR (bpm) | QTc (ms) | QRS (ms) | |||
| Normal | 192.20 ± 5.00 | 2.91 ± 0.06 | 339.20 ± 7.33 | 188.70 ± 6.08 | 44.50 ± 1.67 |
| Escitalopram | 200.00 ± 5.70 | 2.82 ± 0.07 | 330.00 ± 6.73 | 184.50 ± 3.91 | 43.80 ± 1.60 |
| Diabetes | 259.80 ± 12.55* | 3.35 ± 0.03* | 297.80 ± 5.53* | 216.30 ± 4.01* | 57.31 ± 1.30* |
| Diabetes + Escitalopra | 242.60 ± 4.55* | 3.07 ± 0.08# | 327.80 ± 5.41# | 193.00 ± 5.37# | 49.32 ± 1.31# |
BW: body weight, HR: heart rate, HWI: heart weight index which is equal to heart weight (mg)/body weight (g). Each value represents the mean of six experiments ±SEM. Statistical analysis was done using ne way ANOVA followed by Tukey’s post-hoc test.*p < 0.05 vs. normal, # p < 0.05 vs. diabetes.