Table 7.
The summary of Notch signaling differentiating BC, CC, OV, and EC.
| Group | Gene | BC | CC | OV | EC |
|---|---|---|---|---|---|
 | |||||
| A: LIGANDS, RECEPTORS, AND MODULATORS | |||||
| Delta | DLL1 | ↑ | |||
| DLL3 | ↓ | ↓ | |||
| DLL4 | ↑ | ↑ | |||
| Serrate | JAG1 | ↓ | ↓ | ↑ | |
| JAG2 | ↑ | ↑ | |||
| Fringe | LFNG | ↓ | ↑ | ↑ | |
| MFNG | ↑ | ↑ | ↓ | ↑ | |
| RFNG | ↑ | ↑ | |||
| TACE | ADAM17 | ↑ | ↓ | ↓ | |
| Notch | NOTCH1 | ↓ | ↑ | ||
| NOTCH2 | ↓ | ||||
| NOTCH3 | ↓ | ||||
| NOTCH4 | ↓ | ↓ | |||
| Dvl | DVL1 | ↑ | ↓ | ↓ | |
| DVL2 | ↑ | ||||
| DVL3 | ↓ | ↓ | |||
| Numb | NUMB | ↑ | ↓ | ||
| NUMBL | ↑ | ↓ | ↓ | ||
| Deltex | DTX1 | ↑ | ↑ | ||
| DTX2 | ↓ | ↑ | ↑ | ||
| DTX3 | ↑ | ↓ | |||
| DTX3L | ↑ | ||||
| DTX4 | |||||
| γ-secretase complex | PSENEN | ↑ | ↓ | ||
| PSEN1 | ↑ | ↓ | ↑ | ||
| PSEN2 | ↑ | ↑ | |||
| NCSTN | ↓ | ↑ | |||
| APH1A | ↓ | ↓ | |||
| APH1B | ↑ | ↑ | ↑ | ↓ | |
| B: SIGNAL TRANSDUCTION | |||||
| MAML | MAML1 | ↓ | |||
| MAML2 | ↑ | ||||
| MAML3 | ↓ | ↓ | |||
| HATs | CREBBP | ↓ | ↓ | ↓ | |
| EP300 | |||||
| KAT2A | ↑ | ↓ | |||
| KAT2B | ↑ | ||||
| SKIP | SNW1 | ↓ | |||
| CSL | RBPJL | ↓ | ↓ | ||
| RBPJ | ↓ | ↑ | |||
| CtBP | CTBP1 | ↓ | ↓ | ||
| CTBP2 | ↑ | ↑ | ↓ | ||
| HDAC | HDAC1 | ↑ | |||
| HDAC2 | ↓ | ||||
| ATXN1/L | ATXN1 | ↓ | |||
| ATXN1L | |||||
| CIR | CIR1 | ↓ | |||
| SMRT | NCOR2 | ↑ | ↓ | ||
| C: TRANSCRIPTION FACTORS | |||||
| Hes1/5 | HES1 | ↓ | ↑ | ↑ | |
| HES5 | ↓ | ||||
| Hey | HEY1 | ↓ | ↑ | ||
| HEY2 | ↓ | ↑ | ↑ | ||
| HEYL | ↓ | ↓ | |||
| PreTα | PTCRA | ↓ | ↑ | ↑ | |
The up arrow indicates the higher expression of a particular Notch member associated with favorable DFS prognosis and the down arrow indicates the lowered expression of a particular Notch member correlating with better DFS.