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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2020 Nov 24;41(1):446–457. doi: 10.1161/ATVBAHA.120.314944

Figure 3: Inhibition of autophagy in non-CAD arterioles switches the mechanism of FMD.

Figure 3:

(A, B) Overnight inhibition of autophagy via the lysosomal inhibitor BAFA1 switches the mechanism of FMD in atrial and adipose arterioles from NO to H2O2; (C) Overnight incubation with Atg3 siRNA switches the mechanism of dilation in adipose arterioles from NO to H2O2; (D) scramble ATG3 siRNA does not affect the mechanism of dilation in non-CAD adipose arterioles. (E) Smooth muscle responses to papaverine are not affected by autophagy inhibition. * P < 0.05 vs. control; BAFA1, bafilomycin A1; L-NAME, NG-Nitro-l-arginine methyl ester; Peg-Cat; polyethylene glycol-catalase.