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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Nov 19;1866(2):158856. doi: 10.1016/j.bbalip.2020.158856

Fig. 6.

Fig. 6.

Role of different sphingolipids in regulation of TRPML1 channel activity. A. Representative whole lysosome currents enhanced by ML-SA1 in different doses. B. ML-SA1 enhanced TRPML1 channel activity of lysosomes isolated from podocytes of WT/WT mice in a concentration-dependent manner (n = 5). C. ML-SA1 failed to enhance TRPML1 channel activity of lysosomes isolated from podocytes of Asah1fl/fl/Podocre mice (n = 6). D. Summarized data of the effects of various sphingolipids on whole lysosome currents of lysosomes isolated from podocytes of WT/WT mice (n = 3–5). E. Summarized data of the effects of various sphingolipids on whole lysosome currents of lysosomes isolated from podocytes of Asah1fl/fl/Podocre mice (n = 4–6). *p < 0.05 vs. Ctrl group, #p < 0.05 vs. Vehl group. Ctrl, control; Vehl, vehicle; SM, sphingomyelin; Cer, C16 ceramide; Sph, sphingosine.