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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Nov 19;1866(2):158856. doi: 10.1016/j.bbalip.2020.158856

Fig. 7.

Fig. 7.

Inhibition of exosome release by enhancement of TRPML1 channel activity. A. Representative images and summarized data showing that Sph (10 μM) but not Cer (10 μM) remarkably inhibited exosome secretion from podocytes of Asah1fl/fl/Podocre mice (n = 6–8). B. Representative images and summarized data showing that Sph but not Cer significantly enhanced lysosome-MVB interaction in podocytes lacking Asah1 gene (n = 5–9). Scale bars = 20 μm. *p < 0.05 vs. WT/WT group, #p < 0.05 vs. Vehl group. Vehl, vehicle; Cer, C2 ceramide; Sph, sphingosine.