TABLE 1.
Nor | HFD | SalBL | SalBM | SalBH | |
---|---|---|---|---|---|
BW, g | 30.27 ± 1.07 | 34.72 ± 0.94** | 35.98 ± 1.51** | 33.3 ± 0.86* | 34.18 ± 1.12* |
KW, g | 0.40 ± 0.11 | 0.48 ± 0.20** | 0.49 ± 0.17** | 0.49 ± 0.12** | 0.48 ± 0.14** |
BG, mmol/L | 5.59 ± 0.45 | 7.61 ± 0.35** | 7.74 ± 0.23** | 7.74 ± 0.41** | 8.01 ± 0.36** |
UO, ml/24 h | 1.99 ± 0.21 | 1.32 ± 0.09** | 1.27 ± 0.13** | 1.48 ± 0.08* | 1.83 ± 0.14# |
URP, mg/24 h | 7.39 ± 1.38 | 14.60 ± 2.72** | 10.91 ± 1.35 | 12.98 ± 0.96 | 8.79 ± 1.03# |
Cys-C, ng/ml | 470.28 ± 25.71 | 536.15 ± 17.12* | 506.40 ± 17.31 | 514.23 ± 29.34 | 466.09 ± 22.87# |
S-Cr, μmol/L | 11.52 ± 0.37 | 15.08 ± 0.55** | 13.41 ± 0.63 | 13.02 ± 0.53## | 12.06 ± 0.98## |
Data are represented as means ± SEM (n = 6–10). Nor, mice fed with normal diet; HFD, mice fed with high-fat diet; SalBL, SalBM, or SalBH, mice fed with high-fat diet and treated with low dosage of SalB (3 mg/kg), medium dosage of SalB (6.25 mg/kg), or high dosage of SalB (12.5 mg/kg), respectively; BW, body weight; KW, kidney weight; BG, blood glucose; UO, urine output; URP, urinary protein; Cys-C, cystatin C; S-Cr, serum creatinine. *p < 0.05 and **p < 0.01, compared with Nor; # p < 0.05 and ## p < 0.01, compared with HFD.