Table 1.
Summary MHC-I signaling in macrophages and dendritic cells.
| Cell type | MHC-I stimulation | Signaling | Cell outcome | Ref |
|---|---|---|---|---|
| Guinea pig alveolar macrophages | Guinea pig IgG1 and -2 antibodies | – | In combination with Fc-receptor stimulation, ↑ or ↓ release of oxygen free radicals | (31) |
| Mouse peritoneal macrophages | TLR ligands, bacteria, monoclonal antibodies (anti-H-2Kb; AF6-88.5) | ↑ Fps, SHP-2 ↓TRAF6, NF-κB | ↓ TLR response | (9) |
| Mouse bone marrow-derived macrophages | VSV infection, IFN-β | ↑ SHP2 ↓STAT1, ISG |
↓ type I IFN signaling and ↑ viral infection | (6) |
| Human monocyte-derived dendritic cells | Synapse with CD8+ T cells or beads coated with mouse anti HLA-A2 antibodies | – | Remodeling of recycling endosomes from vesicular to tubular structures | (32) |
| Mouse bone marrow-derived dendritic cells | β2-microglobulin knock out mice | – | Increased production of TNF, IL-6 and IFN-β after TLR stimulation | (9) |