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. 2020 Dec 15;14:568200. doi: 10.3389/fnins.2020.568200

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Copyright © 2020 Karunakaran.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Evaluation of reversal learning in APP/PS1 mice using the Morris water maze. (A) Acquisition of reversal learning where the platform was placed in the opposite SW quadrant. Performance was evaluated as average escape latency between 2-month-old wild-type (WT; dark circle) and APP/PS1 (light circle) mice. (B) Reference memory was evaluated 2 h after the last trial on day 11. (C) Percentage changes in search strategies between WT vs. APP/PS1 during days 7–11 of reversal learning. Data are presented as mean ± SEM; n = 18. *P = 0.0332, **P = 0.0021, ****P < 0.0001.