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. 2020 Dec 15;11:597395. doi: 10.3389/fphys.2020.597395

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Copyright © 2020 Ma, Gaynullina, Schmidt, Mladenov and Schubert.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of retigabine and NS19504 on methoxamine-induced contractions of the saphenous artery of young rats. (A) Normalized tension of saphenous arteries at different methoxamine concentration in the absence of potassium channel active agents (Control), in the presence of retigabine (Retigabine 10^–5M), in the presence of NS19504 (NS19504 6^∗10^–6M) and in the combined presence of retigabine and NS19504 (Retigabine + NS19504). (B) Retigabine anti-contractile effect in the absence (Control) and presence of NS19504 (NS19504 6^∗10^–6M). (C) NS19504 anti-contractile effect in the absence (Control) and presence of retigabine (Retigabine 10^–5M). n = 16; ^∗∗p < 0.01; ^∗∗∗p < 0.001.