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. 2020 Dec 15;11:597395. doi: 10.3389/fphys.2020.597395

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Copyright © 2020 Ma, Gaynullina, Schmidt, Mladenov and Schubert.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Summary of the role of BK and KV7 channels in saphenous arteries of young and adult rats. In vessels from adult rats BK and Kv7 channels evoke a similar negative feedback regulation on vessel contraction whereby BK channels produce a considerable functional inhibition on Kv7 channels. In vessels from young rats BK and Kv7 channels evoke different negative feedback regulation on vessel contraction with Kv7 channels dominating. BK channels produce almost no functional inhibition on Kv7 channels.