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. 2020 Dec 15;11:597395. doi: 10.3389/fphys.2020.597395

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Copyright © 2020 Ma, Gaynullina, Schmidt, Mladenov and Schubert.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of retigabine and IBTX on methoxamine-induced contractions of the saphenous artery. (A1,A2) Normalized tension of saphenous arteries with different methoxamine concentrations in the absence of potassium channel active agents (Control), in the presence of IBTX (IBTX 10^–7M), in the presence of retigabine (A1: Retigabine 3*10^–6M; A2: Retigabine 10^–5M) and in the combined presence of retigabine and IBTX (Retigabine + IBTX). (B1,B2) Retigabine anti-contractile effect in the absence of (Control) and presence of IBTX (IBTX 10^–7M). (C1,C2) IBTX contractile effect in the absence of (Control) and presence of retigabine (C1: Retigabine 3*10^–6M, C2: Retigabine 10^–5M). n1 = 9, n2 = 9; *p < 0.05, **p < 0.01; ***p < 0.001.