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. 2020 Dec 15;11:566732. doi: 10.3389/fimmu.2020.566732

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Copyright © 2020 van Dam, Oskam, Kamerling, Arends, Bredewold, Berkowska, van Dongen, Rabelink, van Kooten and Teng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes of circulating ANCAs associated with changes of naive and memory B-cells but not with plasma cells after RTX (A). Individual percentage change as compared to baseline of anti-PR3 and anti-MPO IgG serum levels after remission-induction with RTX treatment (n = 5) (B). Individual percentage change as compared to baseline of anti-PR3 and anti-MPO IgG serum levels is shown for each patient that received RTX as maintenance treatment (n = 8) (C). Heatmap of the Spearman correlations of changes in anti-MPO IgG (n = 6) and anti-PR3 IgG (n = 8) with changes in B-cell subsets as compared to baseline for all timepoints (n = 14). Gradients indicates Spearman’s R. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.